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Wellcome Library

Italian and American scholars found in the skin substances regulating the recovery of wounds. They can be the basis for effective early recovery. Proceedings published in the journal Proceedings of the National Academy of Sciences♪

Staff of the Italian Institute of Technology in Genoa, the San Gallicano Dermatological Institute in Rome and the University of California in Irwin found in the skin of mice hydrolames of fatic acids (GAHC) enzyme, inspiring several classes of biologically active substances. These substances include ethanolamides of polyenacetic fatic acids that activate cannabinoid receptors; ethanolamides of saturated and mono-navigated fatic acids acting on the transcryption factor PPAR-α (receptor of alpha activated by the polypheric peroxide) and amids of long-chain fatic acids

The localization of the GAWC in the skin has led scientists to believe that the enzyme can participate in the processes healing wounds♪ The Genetic and Pharmacological Locking of the GAWC confirmed this guess - surgical cuts in mice were much faster than normal conditions. In an experiment with human cell cultures, it has stimulated the profiling of ceratinocytes and vibration regions, a process responsible for skin recovery.

Since the enzyme operates through the inactivation of biologically active compounds, researchers have searched for the target responsible for early recovery. Chromatographic mass spectrometry of leather psychic spectrometry, followed by statistical modelling, showed that the substances sought were N-teraconaylthaurin, or NAT(24:0), N-eicozanoilthaurin, or NAT(20:0).

Further experiments have shown that the contents of these substances in the edges of the fresh wound are drastically reduced compared to the intact skin and re-established during recovery. The treatment of the edges of the wounds of synthetic NAT(24:0) and NAT(20:0) has caused a dose-dependent acceleration of recovery in the mice. The same substances, added to the culture of human ceratinocytes and vibreblasts, have stimulated processes corresponding to early recovery.

Screening NAT action on various molecular leather signals has shown that it is associated with phosphorusing receptors to the epulphur growth factor and increasing intra-cellular calcium concentration, processes that are key to recovery.